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As a result, brown or black pigment will appear on the mucosal membranes.28 Some macrophages with abundant pigments may be present in the submucosal layer, submucosal lymphatic vessels and some other parts of the organ.21 In addition, GNG5, LPAR3, MAPK8, and PSMC6 might be candidate biomarkers associated with apoptosis in MC.29 Yamate et al.30 speculated that as the apoptosis of the mucosal epithelium or lamina propria layer is reduced, it could delay the progression of MC